Research and Publications - Dr Matthew Banks

Research

Barrett's oesophagus Research
There are multiple trials into Barrett's oesophagus at University College London Hospitals several of which are described below. Dr Matthew Banks is either a chief investigator or investigator in many of these trials:
Barrett's oesophagus in obese, normal weight-obese and normal weight patients
Chief Investigator: Dr. Matthew Banks UCLH
We are trying to understand the relationship between weight and Barrett's oesophagus. We believe that obesity and metabolic markers of obesity are related to acid reflux and the development of Barrett's oesophagus.
The UK HALO Registry
This is a registry of all patients being treated with HALO radiofrequency ablation (RFA) for dysplasia (pre-cancerous changes) and early cancer in Barrett's oesophagus. It is run from UCL Hospitals and collects all the data and outcomes of the treatment in the whole of the UK. WE have shown so far that HALO RFA is a safe, effective and durable over time.
Pro-BOOST - prospective randomised controlled trial of Barrett's Oesophagus surveillance using high definition white light endoscopy, with and without enhanced Optical imaging and Spectroscopy to Target high risk lesions.
We are investigating whether advanced endoscopic imaging technology can accurately diagnose dysplasia in patients with Barrett's oesophagus. We envisage that the technology will improve the detection of pre-cancerous and cancerous lesions and improve outcomes in these patients.
BOSS – Barrett's Oesophagus Surveillance Study
This is a large national study assessing whether surveillance endoscopy for non-dysplastic Barrett's is an effective strategy for detecting and treating dysplasia and cancer
BEST2 - Evaluation of a Non-Endoscopic Immunocytological Device (Cytopill) for Barrett's Oesophagus Screening
The aim of this study is to assess whether a swallowed pill/sponge can stratify the risk of cancer in patients with heartburn. A pill on a string is swallowed which then opens up into a sponge in the stomach. This is then removed through the oesophagus and out of the mouth picking up cells from the oesophagus. The cells are then analysed for specific 'cancer-risk' markers.
Bowel cancer screening Research
Comparison of 2 optical technologies in the Bowel Cancer Screening Program
Chief Investigator: Matthew Banks, UCLH
We are investigating whether the latest technology improves the detection of polyps, the precursor of cancer and early small colon cancers.
Missed colorectal cancer detection
We are measuring the rate of missed cancers during colonoscopy in 3 large endoscopy centres in London and the reasons for this to improve overall performance
Gastrointestinal bleeding Research
HALT-IT
Principal Investigator (UCLH): Matthew Banks
We are investigating whether a pro-clotting drug reduces bleeding in gut in patients who develop bleeding ulcers and other causes of bleeding in the gut.

Publications

Reviews
Banks MR
Should patients expect their colonoscopy to reach the standards experienced by bowel cancer screening patients?
Frontline Gastroenterol 2012;3:122-123

Mannath J, Banks MR
Emerging technologies in Endoscopic Imaging
F1000 Med Rep. 2012;4:3. Epub 2012 Feb 1.

Kent A & Banks MR
Functional Gastrointestinal Disorders: Diarrhea
Gastroenterology Clinics of North America. Hunt (eds),
Sept 2010;39(3):495-507

Banks M.
The modern investigation and management of gastro-oesophageal reflux disease. Clinical Medicine
2009;9(6):1-5

Burleigh DE & Banks MR
Stimulation of intestinal secretion by vasoactive intestinal peptide and cholera toxin. Autonomic Neuroscience.
2007;133(1):64-75

Farthing MJG, Casburn-Jones A, Banks MR
Diarrhoea. Prescriber 2003;14 (20):48-59.

Farthing MJG, Casburn-Jones A, Banks MR.
Getting control of intestinal secretion: thoughts for 2003.
Digestive and Liver Disease 2003;35:378-385

Banks MR, Farthing MJG.
Fluid and electrolyte absorption. Current Opinion in Gastroenterology 2001;
18 (2): 176-181.

Banks MR, Farthing MJG.
Current management of Acute Diarrhoea. Prescriber 2001;
12(12):83-93.

Banks MR, Farthing MJG.
The Management of Acute Diarrhoea. Prescriber 2000;
11(4): 97-105

Case reports
Pasha Y, Banks M.
Medical mystery: an unusual cause of anaemia
Br J Hosp Med (Lond). 2010 Feb;71(2):113.

Pasha Y, Pickard L, Cohen P, Banks MR
An unusual endoscopic diagnosis for acute epigastric pain
Scand J Gastro 2008;43(9):1151-2.

Pasha Y, White WJ, Chew NS, Banks M.
The importance of never ignoring an unexplained metabolic acidosis. Incarcerated femoral hernia. QJM.
2008 Oct;101(10):825-6. Epub 2008 Aug 28.

Green L, Banks MR
HIV associated encephalopathy, a grey case. Int J STD's AIDS.
1995; 6: 744

Original papers
Radiofrequency ablation for early oesophageal squamous neoplasia: Outcomes form United Kingdom registry.
Rehan J Haidry, Mohammed A Butt, Jason Dunn, Matthew Banks, Abhinav Gupta, Howard Smart, Pradeep Bhandari, Lesley Ann Smith, Robert Willert, Grant Fullarton, Morris John, Massimo Di Pietro, Ian Penman, Marco Novelli, Laurence B Lovat
World Journal of Gastroenterology 09/2013; 19(36):6011-6019. 2.47

Radiofrequency Ablation (Rfa) And Endoscopic Mucosal Resection For Dysplastic Barrett's Esophagus And Early Esophageal Adenocarcinoma: Outcomes Of Uk National Halo Rfa Registry.
R J Haidry, J M Dunn, M A Butt, M Burnell, A Gupta, S Green, H Miah, H L Smart, P Bhandari, L Smith, R Willert, G Fullarton, M Di Pietro, C Gordon, I Penman, H Barr, P Patel, P Boger, N Kapoor, B Mahon, J Hoare, R Narayanasamy, D O'Toole, E Cheong, N C Direkze, Y Ang, M Novelli, M R Banks, L B Lovat
Gastroenterology. 2013 Mar 28. doi:pii: S0016-5085(13)00459-9. 10.1053/j.gastro.2013.03.045

Wallace MB, Crook JE, Saunders M, Lovat L, Coron E, Waxman I, Sharma P, Hwang JH, Banks M, DePreville M, Galmiche JP, Konda V, Diehl NN, Wolfsen HC.

Multicenter, randomized, controlled trial of confocal laser endomicroscopy assessment of residual metaplasia after mucosal ablation or resection of GI neoplasia in Barrett's esophagus.

Gastrointest Endosc. 2012 Sep;76(3):539-47.e1. doi: 10.1016/j.gie.2012.05.004. Epub 2012 Jun 28

Dunn JM, Mackenzie GD, Banks MR, Mosse CA, Haidry R, Green S, Thorpe S, Rodriguez-Justo M, Winstanley A, Novelli MR, Bown SG, Lovat LB.

A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett's oesophagus.

Lasers Med Sci. 2012 Jun 15

Banks MR, Haidry R, Butt MA, Whitley L, Stein J, Langmead L, Bloom SL, O'Bichere A, McCartney S, Basherdas K, Rodriguez-Justo M, Lovat LB.

High resolution colonoscopy in a bowel cancer screening program improves polyp detection. World J Gastroenterol. 2011 Oct 14;17(38):4308-13.

Dunn JM, Banks MB, Oukris D, McKenzie GD, Thorpe S, Winstanly A, Novelli MR, Bown S, Lovat LB. Radiofrequency ablation is an effective treatment for high grade dysplasia in Barrett’s esophagus after failed Photodynamic therapy - a case series. Endoscopy. 2011 Jul;43(7):627-30

Dunn JM, Mackenzie GD, Oukrif D, Mosse CA, Banks MR, Thorpe S, Sasieni P, Bown SG, Novelli MR, Rabinovitch PS, Lovat LB

Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high-grade dysplasia and adenocarcinoma in Barrett's oesophagus following photodynamic therapy. Br J Cancer 2010 May 25;102(11):1608-17

Kent AJ, Graf B, Prasad P, Banks M, Feher M. Diabetes Treatments, Gastrointestinal Symptoms and lower Gastrointestinal Endoscopy. Br J Diabetes & Vasc Dis 2009; 9: 129

Banks MR, Farthing MJG, Robberecht P, Burleigh DE. Anti-secretory actions of a novel vasoactive intestinal polypeptide (VIP) antagonist. British J Pharmacol 2005; 144: 994-1001.

Banks MR, Golder M, Farthing MJG, Burleigh DE. Intracellular potentiation between two second messenger systems may contribute to cholera toxin-induced intestinal secretion in humans.GUT 2004;53:50-57

Mulcahy HE, Kelly P, Banks MR, Connor P, Patchet SE, Farthing MJG, Fairclough PD, Kumar PJ. Factors Associated with Tolerance to, and Discomfort with, Unsedated Diagnostic Gastroscopy. Scand J Gast 2001; 36: 1352-1357

Banks MR, Kumar PJ, Mulcahy HE. Pulse Oximetry saturation levels during routine unsedated diagnostic upper gastrointestinal endoscopy. Scand J Gast 2001; 36: 105-109.

Pollock RCG, Banks MR, Fairclough PD, Farthing MJG. Dilutional diarrhoea – underdiagnosed and over-investigated.Europ J Gast Hep. 2000; 12: 1-3

Rockall AG, Lamb GM, Banks MR, Barrett SP, Al-Kutoubi MA. A prospective study of bacteraemia and bacterial contamination rates of catheters and wires during angiography.J Intervent Radiol 1997; 12; 107-111.

Books
Endoscopy in The Cancer Patient
Eds: Banks MR, Deutch J. Wiley, Oxford. 1st Ed. 2013
Chapters
Banks M, Deutsch J
Introduction to Gastrointestinal Endoscopy in the Cancer Patient
Endoscopy in The Cancer Patient. 1st Ed.
Eds: Banks MR, Deutch J. Wiley, Oxford 2013

Haidry R, Banks M
Staging of Premalignant and Malignant Conditions of the Esophagus
Endoscopy in The Cancer Patient. 1st Ed.
Eds: Banks MR, Deutch J. Wiley, Oxford 2013

Dunn J, Haidry R, Banks M
Endoscopic management of Premalignant and early malignant diseases of the esophagus
Endoscopy in The Cancer Patient. 1st Ed.
Eds: Banks MR, Deutch J. Wiley, Oxford 2013

Mannath J, Banks M, Bown S
Palliation of Advanced Tumours of the Stomach
Endoscopy in The Cancer Patient. 1st Ed.
Eds: Banks MR, Deutch J. Wiley, Oxford 2013

Banks MR & Farthing MJG
Disorders of defaecation: Diarrhea. In: Textbook of Clinical Gastroenterology and Hepatology. Hawkey CJ, Bosch J, Richter JE, G Garcia-Tsao, FL Chan (eds).2nd Ed.
Chapt 6. Wiley-Blackwell, London 2012

Banks MR, Wee L & Webster G
Sedation and Monitoring in Endoscopy. In: Clinical Gastrointestinal Endoscopy. Ginsberg, Kochman, Norton, Gostout (eds).
Elsevier Science, London 2011.
Banks MR, & Webster G
Sedation and Monitoring in Endoscopy. In: Clinical Gastrointestinal Endoscopy. Ginsberg, Kochman, Norton, Gostout (eds).
Elsevier Science, London 2005.

Banks MR & Farthing MJG
Infective diarrhoeal diseases. In: Gastroenterology and Hepatology: The Modern Clinician’s Guide. Weinstein WM, Hawkey CJ, Bosch J (eds).
Chapt 10. Elsevier Science, London 2002.

Banks MR & Burleigh DE
Anti-diarrhoeal drugs. In: Encyclopedia of Gastroenterology. Johnson RL (ed).
Elsevier, San Diego 2003, 94-98.

Banks MR & Fairclough PD
The treatment of gastrointestinal bleeding. In: Drug therapy of gastrointestinal and liver disease. Farthing MJG & Ballinger AB (eds).
Martin Dunitz, London 2001, 63-74.

Videos
Banks M, Johnson G.
Endoscopic submucosal dissection of a carcinoma-in-situ of the gastric antrum
ASGE Video Learning Centre & DAVE PROJECT. May 2010.

Banks M, Johnson G.
Gastropleural fistula complicating oesophagectomy: endoscopic closure using absorbable vicryl mesh and fibrin glue
ASGE Video Learning Centre & DAVE PROJECT. May 2010.

Abstracts
Khan MS, Haidry, RI, Butt, MA, Banks, MR, bown SG, lovat, LB
Single centre experience of oesophageal stent insertion for benign and malignant strictures
DDW

MA Butt, H Pye, RJ Haidry, D Oukrif, M Rashid, MR Banks, MP Deonarian, MR Novelli, LB Lovat.
Aberrantly glycosylated MUC1 as a potential therapeutic target for Barrett’s with high grade dysplasia and primary and metastaticc adenocarcinoma
GUT 2012;61(2):A301

MA Butt, RJ Haidry, D Oukrif, J Dunn, A Gupta, M Bhatt, L Hrynjiewicz, A Waheed, C Owen, A Machhada, M Rodriguez-Justo, MR Banks, LB Lovat, MR Novelli.
Polo-like kinase 1 Expression predicts aneuploidy in the Barrett’s metaplasia-dysplasia-carcinoma sequence.
GUT 2012;61(2):A302

MA Butt, RJ Haidry, D Oukrif, H Pye, I Stamati, G Yahioglu, M Rodriguez-Justo, MR Banks, MP Deonarian, MR Novelli, LB Lovat.
HER2 expression in the Barrett’s Metaplasia-dysplasia-carcinoma sequence and potential targeting in vitro with single chain antibody fragment C6.5
GUT 2012;61(2):A302

RJ Haidry, LB Lovat, M Banks, A Gupta, MA Butt, M Novelli, T Kosciolek, A Marechal, P Rich.
Infrared spectroscopy accurately detects Barrett’s mucosa biopsy specimens Ex vivo
GUT 2012;61(2):A307

RJ Haidry, J Dunn, M Banks, A Gupta, MA Butt, H Smart, P Bhandari, LA Smith, E Willert, G Fullarton, M Di Pietro, I Penman, M Novelli, LB Lovat.
Halo RFA ablation for squamous high grade dysplasia and early squamous cell carcinoma: Outcomes from the UK HALO RFA registry
GUT 2012;61(2):A307

RJ Haidry, J Dunn, M Banks, A Gupta, MA Butt, H Smart, P Bhandari, LA Smith, E Willert, G Fullarton,
M Di Pietro, I Penman, H Barr, C Gordon,P Patel, P Bodger, N Kappor, B Mahon, M Burnell, M Novelli,
LB Lovat

Halo RFA ablation for high grade dysplasia and early mucosal neoplasia arising in Barrett’s oesophagus: Outcomes from the UK HALO RFA registry
GUT 2012;61(2):A308

R Haidry, J Dunn, S Thorpe, G Fullarton, H Smart, P Bhandari, N Kapoor, P Patel, R Willert, M Novelli,
I Penman, M Banks, L Lovat Is Radiofrequency Ablation more effective following Endoscopic
Resection for eradication of High Grade Dysplasia/ Intramucosal cancer arising in Barrett’s
oesophagus? Results from the UK RFA registry.
(POSTER)Gastroenterology Vol. 140, Issue 5, Supplement 1, Page S-215

P Sellaturay, R Haidry, J Dunn, S Green, M Rodriguez-Justo, A Winstanley, M Novelli, M Banks, L Lovat
Appropriate staging renders Ablative therapy safe for High Grade Dysplasia in Barrett’s Oesophagus. (POSTER)
Gut 2011;60:A201-A202 doi:10.1136/gut.2011.239301.424

Jason M. Dunn, Gary D. Mackenzie, Sally Thorpe, Martin Austwick, Charles A. Moss, Dahmane Oukrif, Manuel Rodriguez-Justo, Alison Winstanley, Marco Novelli, Matthew R. Banks, Stephen G. Bown1, Laurence Lovat. A Randomised Controlled Trial of ALA v Photofrin PDT for High Grade Dysplasia in Barrett’s Esophagus. (1018208) DDW 2011.

Rehan J. Haidry, Jason M. Dunn, Sally Thorpe, Grant Fullarton, Howard Smart, Pradeep Bhandari,
Neil Kapoor, Praful Patel, Robert P. Willert, Ian D. Penman, Matthew R. Banks, Laurence B. Lovat.
Radio Frequency Ablation is more effective in shorter segments of Barrett’s Oesophagus for eradication
of High Grade Dysplasia/ Intramucosal Cancer – Resultsfrom the UK RFA HALO Registry.
(1032070 ) DDW 2011

Matthew R Banks, Lisa Whitley, Judith Stein, Louise Langmead, Stuart L Bloom, Austin O’Bichere, Sara McCartney, Kalpesh Basherdas1,Manuel Rodriguez-Justo2, Laurence B Lovat
Polyp Detection is Improved by Megapixel White Light High Resolution Colonoscopy in the UK National Bowel Cancer Screening Program (1032045).
DDW 2011.

Dunn JM, Thorpe S, Fullarton GM, Smart H, Penman I, Patel P, Willert R, Novelli MR, Banks M, Lovat LB.
Radiofrequency ablation for HGD or IMC in Barrett’s Esophagus – results from the first 100 patients enrolled in the UK HALO.
Gastrointestinal Endoscopy 2010:71(5);AB176.

Gupta A, Dunn JM, Thorpe SM, Banks MR, Bown SG, Lovat LB. "Pattern distribution of Barrett's oesophagus
based on two-dimensional reconstruction of macroscopic findings at endoscopy.
" Annual General Meeting of the British-Society-of-Gastroenterology.
2010-04-01. doi:10.1136/gut.2009.208983u

Dunn JM, Thorpe S, Fullarton GM, Smart H, Penman J, Patel P, Willett R, Novelli MR, Banks MR, Lovat LB.
"Endoscopic radiofrequency ablation for high-grade dysplasia or intramucosal cancer in Barrett's
oesophagus - results from the first 100 patients enrolled in the uk halo radiofrequency ablation registry.
" Annual General Meeting of the British-Society-of-Gastroenterology.
2010-04-01. doi:10.1136/gut.2009.208983s

Dunn JM, Oukrif D, Mackenzie GD, Banks MR, Novelli MR, Lovat LB.
Comparison of Image cytometric DNA analysis of brush cytology specimens versus formalin fixed tissue in Barrett’s oesophagus.
DDW 2010

Dunn JM, Jiao Y, Austwick M, Mosse CA, Oukrif D, Thorpe S, Novelli MR, Banks M, Bown SG, Lovat LB.
Elastic scattering spectroscopy is highly accurate for the detection of high grade dysplasia and DNA
ploidy arising in Barrett’s Esophagus using a red enhanced spectrometer.
DDW 2010

Kent AJ, Graf B, Banks MR. Iatrogenic causes of gastrointestinal symptoms and the impact on endoscopy.
Gastroenterology 2009;136(5)suppl I: P262

Kent AJ, Graf B, Prasad P, Feher MD, Banks MR. Diabetes treatments, gastrointestinal symptoms and lower gastrointestinal endoscopy.
Gastroenterology 2009;136(5)suppl I: P262

Kent AJ, Graf B, Banks MR. Symptoms, endoscopy and physiology: do they correlate? Gut 2009;58(Suppl 1):A141

Banks MR, Jamieson N, Jones DB, Norton I. Power doppler improves EUS diagnosis of metastatic adenopathy.
Gastrointestinal Society of Australia 2004.

Casburn-Jones AC, Banks MR, Farthing MJG. Effects of cholera toxin (CT), Escherichia coli heat labile
toxin (LT) and heat stable toxin (STa) on distant (Neurogenic) Intestinal fluid and electrolyte transport.
Gastroenterology 2003; 124 (4): A-558. (Poster)

Casburn-Jones AC, Banks MR, Farthing MJG. Effects of bacterial enterotoxins on distant (neurogenic)
intestinal fluid and electrolyte transport.
Gut 2003; 52 (1): A369 (Poster)

Banks MR, Farthing MJG, Robberecht P, Burleigh DE
Anti-Secretory Actions of a Novel Vasoactive Intestinal Polypeptide Receptor Antagonist.
Gastroenterology 2002; 122 (4): A-254 (Poster)

Banks MR, Casburn-Jones A, Farthing MJG. Cholera toxin (CT), Escherichia coli heat labile
(LT) and heat stable toxin (STa) have an indirect effect on distal intestinal fluid transport in the rat small intestine.
Gastroenterology 2002; 122 (4): A-144. (Poster)

Banks MR, Casburn-Jones A, Farthing MJG. Cholera toxin (CT) and Escherichia coli heat stable
toxin (STa) induce ab-oral secretion in the rat.
GUT 2001; 49 (3):A2323. (Poster)

Banks MR, Smith GV, Fairclough PD. Endoscopic investigation of anaemia: yield in iron deficiency anaemia,
iron deficiency without anaemia and idiopathic non-iron deficiency anaemia.
Gastrointestinal endoscopy 2001; 53 (5):AB196. (Poster)

Banks MR, Burleigh DE, Farthing MJG. Cholera toxin potentiates responses of T84 human colonic
epithelial cells to acetylcholine, but not to vasoactive intestinal polypeptide.
Gastroenterology 2001; 120 (5):A532. (Poster)

Banks MR, Bose M, Farthing MJG. The effects of the enkephalinase inhibitor racecadotril on
enterotoxin-induced intestinal secretion in the rat.
Gut 2000;47(III):A48. (Speaker)

Banks MR, Bose M, Lunn MP, Farthing MJG. The effects of racecadotril on Eschericia coli
heat labile toxin (LT) induced intestinal secretion.
Gastroenterology 2000;118:A322. (Poster)

Bose M, Banks MR, Lunn MP, Farthing MJG. Effect of the enkephalinase inhibitor, racecadotril,
on intestinal 5-hydroxytyptamine (5-HT) and fluid transport in cholera toxin induced secretion.
Gastroenterology 2000;118:A1118. (Poster)

Mulcahy HE, Banks MR, Farthing MJG, Fairclough PD, Kumar PJ. Factors associated with
tolerance to unsedated upper gastrointestinal endoscopy.
Gastroenterology 1998; 114: A859. (Poster)

Banks MR, Mulcahy HE, Kumar PJ.
Is oxygen monitoring necessary in upper gastrointestinal endoscopy ? Gut 1998; 42: A56. (Poster)

Banks MR, Kirby GC, Warhurst DC.
Comparative study of the uptake of Mepacrine and Rhodamine 1,2,3 into intraerythrocytic Plasmodium
falciparum by fluorescent microscopy. Trans R Soc Trop Med Hyg 1991; 85: 311 (Poster)

BOOK AN APPOINTMENT WITH MATTHEW
To book an appointment select a date from below. We will then contact you to confirm the appointment.
 
Ask Matthew a Question
To contact us please complete this form
Please enter AICRB in below text box.
CONTACT DETAILS
+44 (0) 207 881 4054 Option 2
+44 (0) 207 881 4094