Research and Publications - Dr Michael Chapman

Original papers and reviews
Sandanayake NS, Camuzeaux S, Sinclair J, Blyuss O, Andreola F, Chapman MH, Webster GJ, Smith RC, Timms JF & Pereira SP. Identification of potential serum peptide biomarkers of biliary tract cancer using MALDI MS profiling. BMC Clin Path 2014; 4;14(1):7

Dhar DK, Damink SW, Brindley JH, Godfrey A, Chapman MH, Sandanayake NS, Andreola F, Mazurek S, Hasan T, Malago M, Pereira SP. Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer. Cancer 2013; 119(3):575-85

Chapman MH, Webster GJM, Bannoo S, Johnson GJ, Wittmann J & Pereira SP. Cholangiocarcinoma and dominant strictures in patients with primary sclerosing cholangitis: a 25-year single-centre experience. Eur J Gastro Hep 2012; 24(9):1051-8.

Chapman MH, Andreola F, Sandanayake NS, Tidswell R, Cerec V, Lee A, Swanton RC, Dooley JS & Pereira SP. Whole genome RNA expression profiling of endoscopic biliary brushings provides data suitable for biomarker discovery in cholangiocarcinoma J Hepatol 2012; 56(4):877-8.

Chapman MH, Sandanayake NS, Andreola F, Dhar DK, Webster GJ, Dooley JS & Pereira SP. Circulating CYFRA 21-1 is a highly specific diagnostic and prognostc biomarker in biliary tract cancer. J Clin Exp Hepatol 2011; 1(1):6-12

SandanayakeNS, SinclairJ, Andreola F, Chapman MH, XueA, ClarksonA, Gill A, WebsterGJ,Norton ID, SmithRC, TimmsJF & PereiraSP. A combination of serum leucine-rich alpha-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures. Brit J Cancer, 2011;105(9):1370-8

Kalaitzakis E, Levy M, Kamisawa T, Johnson GJ, Baron TH, Topazian MD, Takahashi N, Kanno A, Okazaki K, Egawa N, Uchida K, Sheikh K, Amin Z, Shimosegawa T, Sandanayake NS, Church NI, Chapman MH, Pereira SP, Chari S &Webster GJM. Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from PSC or cholangiocarcinoma. Clin Gastro Hep 2011; 9(9):800-803

Wadsworth CA, Dixon PH, Wong JH, Chapman MH, McKay SC, Sharif A, Spalding DR, Pereira SP, Thomas H, Taylor-Robinson SD, Whittaker J, Williamson C & Khan SA. Genetic factors in the pathogenesis of cholangiocarcinoma. Dig Dis. 2011;29(1):93-97

Sugumar A, Levy MJ, Kamisawa T, Webster GJ, Kim MH, Enders F, Amin Z, Baron TH, Chapman MH, Church NI, Clain JE, Egawa N, Johnson G, Okazaki K, Pearson RK, Pereira SP, Peterson BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD, Uchida K, Vege SS & Chari ST. Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international multicenter study. Gut 2011;60: 666-670

Matull WR, Dhar DK, Ayaru L, Sandanayake NS, Chapman MH, Dias A, Bridgewater J, Bong JJ, Davidson BR, Pereira SP, R0 but not R1/R2 resection is associated with better survival than palliative photodynamic therapy in biliary tract cancer. Liv Int. 2010; 31(1):99-107

Chapman MH, Kajihara M, Borges G, O’Beirne J, Patch D, Dhillon AP, Crozier A & Morgan MY. Acute severe liver injury associated with chewing khat (cath edulis). NEJM. 2010;362(17):1642-1644

Chapman MH & Pereira SP. Cholangiocarcinoma: Improving biliary drainage with PDT. PDPDT 2009;6(2):82-83

13. Pereira SP, Matull WR, Dhar DK, Ayaru L, Sandanayake NS & Chapman MH. Palliative photodynamic therapy for biliary tract carcinoma improves survival and has a similar outcome to attempted curative surgery with positive resection margins. Proceedings of SPIE. 2009: June:7380

Sandanayake NS, Church NI, Chapman MH, Johnson GJ, Dhar DK, Amin Z, Deheragoda MG, Novelli M, Winstanley A, Rodriguez-Justo M, Hatfield AR, Pereira SP & Webster GJ. Presentation and Management of Post-treatment Relapse in Autoimmune Pancreatitis / Immunoglobulin G4-Associated Cholangitis. Clin Gastroenterol Hepatol. 2009;7(10):1089-96

Chapman MH & Sanderson IR. Intestinal flora and the mucosal immune system. Probiotics in Children, Annales Nestle, 2003;6/12

Garland J, Buscombe JR, Bouvier C, Bouloux P, Chapman MH, Chow AC, Reynolds N & Caplin ME. Sandostatin LAR (long-acting octreotide acetate) for malignant carcinoid syndrome: a 3 year experience. Aliment Pharmacol Ther. 2003;17(3):437-44

Robertson KE, Chapman MH, Adams A, Tickle C, Darling SM. Cellular Analysis of the Mouse Mutant Hypodactyly. Developmental Genetics 1996;19:9-25

Manuscripts due for submission
Chapman MH et al. Achieving confirmatory pathological diagnosis in biliary tract cancer. (Submitted)

Huggett M, Culver EL, Kumar M, Chapman MH, Johnson GJ, Pereira SP, Chapman RW, Webster GJ & Barnes E. IgG4-related autoimmune pancreatitis and cholangitis is associated with extra-pancreatic organ failure, malignancy and mortality in a prospective UK cohort. (Submitted)

Chapman MH et al. Guidelines for the diagnosis and management of primary sclerosing cholangitis and its overlap syndromes.

Chapman MH et al. Sphincter of Oddi Dysfunction (review article).

Book chapters
Cerec V, Chapman MH and Pereira SP. “Gastrointestinal tumourigenesis: the relevance of tumourigenic mechanisms to diagnosis and treatment”. Chapter: Biliary tract cancer. In press, World Scientific Publishing, 2014.

Abstracts
Paranandi B, Cheung V, Joshi D, El-Sayed GH, Johnson GJ, Pereira SP, Webster GJ & Chapman MH. The impact of endoscopic therapy on patient-perceived outcome & quality of life in sphincter of Oddi dysfunction. BSG 2014.

Paranandi B, Joshi D, El-Sayed GH, Patel P, Chapman MH, Pereira SP, Webster GJ & Johnson GJ. Fully covered self expanding metal stents are effective in remodelling benign biliary strictures in patients with chronic pancreatitis. BSG 2014.

Paranandi B, Patel PS, Joshi D, El-Sayed GH, Koshy K, Ghai A, Chapman MH, Pereira SP, Webster GJ & Johnson GJ. Nutritional optimisation and pancreatic enzyme supplementation in chronic pncreatitis: Are we giving enough advice? BSG 2014.

Joshi D, Paranandi B, El-Sayed GH, Chapman MH, Amin Z, Winstanley A, Johnson GJ, Pereira SP & Webster GJ. Cerebral manifestations of IgG4 related disease..International IgG4 symposium. Hawaii 2014. 

Joshi D, Paranandi B, El-Sayed GH, Johnson GJ, Chapman MH, Pereira SP, & Webster GJ. The increasing role of enhanced sedation assisted ERCP: Important lessons for service provision. DDW. Chicago 2014.

Paranandi B, Patel PS, Joshi D, El-Sayed GH, Koshy K, Ghai A, Chapman MH, Pereira SP, Webster GJ & Johnson GJ. The burden of poor nutrition in chronic pancreatitis: What are the impact of behavioural and socioeconomic factors. BSG 2014.

Paranandi B, Cheung V, Joshi D, El-Sayed GH, Johnson GJ, Pereira SP, Webster GJ & Chapman MH. Subjective description of pain does not predict biliary manometry or response to endotherapy in sphincter of Oddi dysfunction. BSG 2014.

Huggett M.H, Pereira S.P, Chapman M.H, Johnson G.J & Webster G.J. Long-term follow up of patients with IgG4 related disease. Pancreatology 13(1):e5. 2013

Sehgal V, Krishnan B, Kumar M, Chapman MH, Pereira SP, Webster GJ & Johnson GJ. A new pancreatobiliary telephone clinic service-improved service delivery, efficiency and patient experience. BSG 2013

Huggett M, Culver E, Kumar M, Chapman M, Johnson G, Pereira S, Chapman R, Webster G, Barnes E. IgG4-related autoimmune pancreatitis and cholangitis is associated with extra-pancreatic organ failure, malignancy and mortality in a prospective UK cohort. UEGW Berlin, 2013.

Skipworth JRA, Chapman MH, Johnson G,Vyas S, Webster GW, Pereira, SP. Bone Mineral Density in Patients with Chronic Pancreatitis. Panc Soc annual meeting, Dublin 2011.

Chapman MH, Bannoo S, Webster GJM, Johnson G, Hatfield AR & Pereira SP. A 25 year single centre experience in 128 patients with primary sclerosing cholangitis. BSG Annual General Meeting, Birmingham 2011

Bannoo S, Chapman MH, Sandanayake NS, Webster GJM, Johnson G, OldeDamink S, Imber C, Malago M & Pereira SP. Achieving pathological diagnosis in biliary tract cancer. BSG Annual General Meeting, Birmingham 2011

Wadsworth CA, Dixon PH, Wong JH, Chapman MH, McKay SC, Sharif A, Spalding DR, Pereira SP, Thomas H, Taylor-Robinson SD, Whittaker J, Williamson C & Khan SA. Common genetic variation in natural killer cell receptor protein G2D does not modify susceptibility to sporadic cholangiocarcinoma. EASL. Berlin. 2011

Skipworth JRA, Zayadine T, Raptis D, Vyas S, Imber C, Humphries S, Chapman MH, Pereira SP, Olde Damink S, Malago M, Shankar A & Montgomery H, The Effect of Renin Angiotensin System Genetic Variants upon outcome from Chronic Pancreatitis. Annual Meeting of EHPBA. Cape Town, SA, 2011

Boughton AL & Chapman MH. Are abnormal liver function tests in people with type 2 diabetes mellitus investigated in general practice? Annual meeting of the RCGP. Harrogate, Oct 2010

Chapman MH, MangaleswaranS, Dhariwal SK, MonemM & AlsteadEM. Recognition of alcohol misuse and impact on admissions in a district general hospital. Falk Symposium, Freiberg, Oct 2010

Wadsworth CA, Dixon PH, Wong JH, Chapman MH, McKay SC, Sharif A, Spalding DR, Pereira SP, Thomas H, Taylor-Robinson SD, Whittaker J, Williamson C & Khan SA. Genetic variability in biliary transporters as a susceptibility factor for cholangiocarcinoma. BASL. Edinburgh 2010

Chapman MH, Mangaleswaran S, Henderson ARR & Alstead EM. Alcohol and liver diseases; recognition and impact on admissions in a district general hospital. BSG Annual General Meeting, Liverpool 2010

Sandanayake NS, Sinclair J, Andreola F, Chapman MH, Camuzeaux S, Webster GJ, Norton ID, Smith RC, Timms JF & Pereira SP. Characterisation of serum proteins in biliary tract cancer, PSC and IAC using 2-dimensional difference gel electrophoresis and tandem mass spectrometry. DDW. New Orleans. 2010

Sandanayake NS, Andreola F, Camuzeaux S, Sinclair J, Chapman MH, Webster GJ, Gentry-Maharaj A, Menon U, Jacobs I, Smith RC, Pereira SP & Timms JF. Serum CEACAM1 in the preclinical diagnosis of pancreatic adenocarcinoma. DDW. New Orleans. 2010

Sandanayake NS, Chapman MH, Kalaitzakis E, Amin Z, Novelli M, Winstanley A, Rodriguez-Justo M, Hatfield AR, Pereira SP & Webster GJ. Do steroids improve the long-term outcome of autoimmune pancreatitis. DDW. New Orleans. 2010

Sandanayake NS, Camuzeaux S, Sinclair J, Chapman MH, Bell C, Norton ID, Webster GJ, Smith RC, Timms JF & Pereira SP. Biliary tract cancer serum profiling using magnetic bead-based peptide extraction and MALDI-TOF mass spectrometry. DDW. New Orleans. 2010

Sugumar A, Levy MJ, Kamisawa T, Baron TH, Topazian MD, Takahashi N, Kanno A, Okazaki K, Egawa N, Uchida K, Sheikh K, Amin Z, Shimosegawa T, Sandanayake NS, Church NI, Chapman MH, Hatfield AR, Pereira SP, Chari ST & Webster GJ. Utility of endoscopic retrograde cholangiography to diagnose IgG4-associated cholangitis: An international, double blind, randomized, multicenter study. DDW. New Orleans. 2010

Wadsworth CA, Dixon PH, Taylor-Robinson SD, Chapman MH, Sharif AW, Pereira SP, Thomas HC, Williamson C & Khan SA. An investigation of the MRP2/ABCC2 single nucleotide polymorphism C.3972C>T (RS4740066) in cholangiocarcinoma. EASL. 2010

Chapman MH, Andreola F, Sandanayake NS, Dooley JS and Pereira SP. Whole genome RNA expression profiling of ERCP biliary brushings in biliary tract cancer. AASLD annual general meeting, Boston, 2009

Chapman MH, Mills R.K, Sandanayake SN & Pereira SP. High success rates for tissue diagnosis in 198 patients with biliary tract cancer. Annual general meeting, BASL, London 2009

NS Sandanayake, S Camuzeaux, MH Chapman, C Bell, ID Norton, AR Hatfield, GJ Webster, RC Smith, JF Timms, SP Pereira. MALDI-TOF MS serum profiling of biliary tract cancer using magnetic bead-based peptide extraction. Annual general meeting, BASL, London 2009

Tidswell R, Chapman MH, Sandanayake NS, Andreola F, Webster GJ, Dooley JS & Pereira SP. Circulating CYFRA 21-1 is a potential marker for cholangiocarcinoma in primary sclerosing cholangitis. EASL Monothematic Meeting on Primary Sclerosing Cholangitis, Oslo, June 2009

Pereira SP, Matull WR, Dhar DK, Ayaru L, Sandanayake NS & Chapman MH. Palliative photodynamic therapy for biliary tract carcinoma improves survival and has a similar outcome to attempted curative surgery with positive resection margins. Annual Meeting of the International Photodynamic Association, Seattle, June 2009

Chapman MH, Sandanayake NS, Andreola F, Dhar DK, Dooley JS & Pereira SP. Circulating CYFRA 21-1 is a highly specific diagnostic and prognostic biomarker in biliary tract cancer. BSG Annual General Meeting, Glasgow 2009

Sugumar A, Levy MJ, Kamisawa T, Kim M-H, Enders F, Amin Z, Baron TH, Chapman MH, Church NI, Clain JE, Egawa N, Johnson GJ, Okazaki K, Pearson RK, Pereira SP, Petersen BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD, Uchida K, Vege SS, Webster G, Chari ST. Utility of Endoscopic Retrograde Pancreatogram (ERP) to Diagnose Autoimmune Pancreatitis (AIP): An International, Double Blind, Randomized, Multicenter Study. DDW, Chicago 2009

Chapman MH, O’Beirne J, Patch D, Dhillon AP, Borges G, Crozier A & Morgan MY. Fulminant hepatic failure related to the chewing of khat. AASLD annual general meeting, San Francisco, 2008

Chapman MH, Andreola F, Sandanayake N, Dooley JS and Pereira SP. Degraded RNA isolated from bile and biliary brushings is suitable for downstream applications such as qPCR. AASLD satellite symposium; Pathobiology of biliary epithelia and cholangiocarcinoma Atlanta, USA 2008

Chapman MH, Wittmann J, Webster GJ, Hatfield AR & Pereira SP. A single centre experience of dominant biliary strictures and cholangiocarcinoma in Primary Sclerosing Cholangitis (PSC). Bile Acid Biology & Therapeutic actions, Falk symposium 65, Amsterdam, 2008

Sandanayake NS, Johnson GJ, Smyth CM, Church NI, Ayaru L, Chapman MH, Hatfield AR, Pereira SP & Webster GJ. Azathioprine in the management of relapsing autoimmune pancreatitis / IgG4 sclerosing cholangitis. BSG annual general meeting, Birmingham 2008

Brindley JH, Dhar DK, Chapman MH, Dooley JS & Pereira SP. Tumour M2-Pyruvate Kinase has a Diagnostic and Prognostic Role in Biliary Tract Cancer. AASLD annual general meeting, Boston. 2007

Baynes C, Chapman M & Farag M. Panhypopituitarism Secondary to Sphenoid Sinus Aspergilloma. Endocrine Abstracts. 2001; 2: p18
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